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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as focusing on practical aspects of designing a study which include recruitment and consent, adherence and the use of standard equipment.

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A pragmatic trial that uses different investigators and participants from diverse geographical locations is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is essential for pragmatic trials to be reliable and reduce bias in results, 프라그마틱 정품 is also necessary. However, too much heterogeneity can cause issues with the design of the trial.

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Pragmatic trials seek to replicate real-world situations and have the highest external validity. They are typically commissioned by policymakers and practitioners to inform their decisions. They can be used to determine the cause-effect relationship of an intervention and its effects. However, 프라그마틱 정품확인방법 they should not be used to substitute for explanation studies.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, which confirm a physiological hypothesis or clinical hypothesis, as well as pragmatic trials, that inform the decision-making process for policy and practice. They also proposed an approach to pragmatic trials, which they called PRECIS.2 This tool was designed to define the elements of a pragmatic study which includes the recruitment process, the design and implementation of the intervention, as well as follow-up.

The number of pragmatic trials is increasing. A recent Medline search using the terms pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This suggests that the health sciences community is becoming more aware of the importance of pragmatism. It is important to keep in mind, however, that the majority of studies were conducted in primary care settings.